PREVENTION OF EXCESS HEMOLYSIS DURING CARDIOPULMONARY BYPASS BY THE USE OF PLURONIC F-68

GORO SAKAUCHI; 松本 弘; 川井 忠和; 石田 常博; 安斉 徹男; 浅海 秀一郎; 長谷川 紳治; 内田 晃亘; 稲村 信正; 野本 親男; 井田 仁一

doi:10.2974/kmj1951.23.231

GORO SAKAUCHI, [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japanese]

Author information

GORO SAKAUCHI
Department of Surg, School of Medicine, Gunma University
[in Japanese]
Department of Surg, School of Medicine, Gunma University
[in Japanese]
Department of Surg, School of Medicine, Gunma University
[in Japanese]
Department of Surg, School of Medicine, Gunma University
[in Japanese]
Department of Surg, School of Medicine, Gunma University
[in Japanese]
Department of Surg, School of Medicine, Gunma University
[in Japanese]
Department of Surg, School of Medicine, Gunma University
[in Japanese]
Department of Surg, School of Medicine, Gunma University
[in Japanese]
Department of Surg, School of Medicine, Gunma University
[in Japanese]
Department of Surg, School of Medicine, Gunma University
[in Japanese]
Department of Surg, School of Medicine, Gunma University

JOURNAL FREE ACCESS

1973 Volume 23 Issue 3 Pages 231-238

DOI https://doi.org/10.2974/kmj1951.23.231

Details

Abstract

Subacute toxicity of Pluronic F-68, a non-ionic surfactant, was investigated with Wister rats.
Three times every other day intraperitoneal injections of Pluronic F-68 at a dose of 1.0, 4.0, 10 or 40 mg/ml produced no gross changes in the kidney and liver.
But the fatty granulas were observed in the renal tubules and in liver.
In 13 open heart surgery 0.6-1.0 mg/ml of Pluronic F-68 were administered in bypass circuit. Pluronic F-68 was very effective to prevent the hemolysis and no significant harmful side effects were recognized in our series.
But special care have to be directed in prolonged extra-corporeal circulation.

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