AN ELECTORON MICROSCOPIC OBSERVATION ON THE MICROVASCULAR CHANGES CAUSED BY HABU SNAKE VENOM, WITH SPECIAL REFERENCE TO HEMORRHAGE
1974 Volume 24 Issue 1 Pages 21-42
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1974 Volume 24 Issue 1 Pages 21-42
Crude Habu snake venom was injected in the femoral muscle of mice and the ultrastructures of the microvessels in the lesions were examined by electoron microscopy. Most of the vessels encountered between the damaged muscle cells were capillaries, partially containing postcapillary venules. The results were as follows.
1. There were various injuries of the endothelial cells, such as formation of villous projections and intravascular blebs from cells, degeneration of cellular organelles, especially decrease and disappearance of pinocytotic vesicles, swelling, darkning and thinning of cells, formation of endothelial gaps and celullar necrosis.
2. The fluffy changes, discontinuities and deficiency of the basement membrane were observed.
3. The hemorrhage by Habu snake venom were occured by discontinuities of both the endothelium and the underlining basement membrane.
4. It is considered that the increasing hemorrhage may be caused not only by the destruction of capillary wall, but also by the disturbance of coagulant activities.
