STUDIES ON THE DISTRIBUTION AND EXCRETION OF PHENYLMERCURY ACETATE
1974 Volume 24 Issue 1 Pages 57-64
Details
1974 Volume 24 Issue 1 Pages 57-64
203Hg-phenylmercury acetate (203Hg-PMA) was given to mice, and its retention, excretion and distribution were investigated. Furthermore various drugs were examined for 203Hg-expelling effect.
1. Retention : the retention after the s.c., i.p. and p.o. administration were daily explored. The biological half-life was short, about 1-2 days in all cases.
2. Excretion : The daily excretion was usually high in feces and low in urine.
3. Distribution : The radioactivity after i.p. administration was highest in the kidney already at 1 hour, and attained the peak at 4 hours. At 1 hour, next in order were the pancreas, blood, liver, spleen, brain successively. At 24 hours, the liver exceeded pancreas.
The subcellular distribution of 203Hg-PMA in the liver and kidney 24 hours after i.p. administration was greater in the supernatant fraction in both organs than the other fractions.
4. Effects of administration of various drugs : In 3 day experiments on the whole-body retention of 203Hg-PMA was decreased by BAL only. L-CySH·Gly., EDTA, ZnSO4 were often found to increase 203Hg retention. BAL decreased 203Hg activity among the kidney, liver, pancreas, spleen, blood, but it significantly increase only the cerebral concentration of 203Hg. 2-Mercaptopropionyl glycine decreased 203Hg concentration in the pancrease and spleen in the experiment after i.p. administration of 203Hg-PMA, and in the kidney in experiment after oral administration of203Hg-PMA.
5. Effect of starvation : The fecal excretion of 203Hg was decreased and the retention of it was increased by the starvation, and they were recovered by feeding.
