THE QUANTITATION OF THE DYNAMIC IMAGE FEATURES
(I) CONSTRUCTION METHOD OF FUNCTIONAL IMAGES
1977 Volume 27 Issue 6 Pages 427-437
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1977 Volume 27 Issue 6 Pages 427-437
The technique for mapping regional organ function by means of the radioisotope (RI) imaging system, is presented. A mathematical model used for constructing functional images is one compartment model, which consists of theoretical disapperance of RI-tracer in blood X1 (t) and uptake of RI-tracer in tissue X2 (t). Sum total X (t) of X1 (t) and X2 (t) is expressed with X (t) =a+b exp (-Ct), which is obtained as results of the curve-fitting by Cornell's method for the observations.
Using the coefficient a, b, C obtained with curve-fitting, parameters of regional organ function derived from the one compartment model are calculated and the maps of each parameter are constructed. Results of applications of the functional imaging technique for clinical studies (i.e., thyroid-dynamic image with Tc-99m-pertechnetate, liver dynamic image with Tc-99m-Sn-colloid and myocardial dynamic image with N-13 ammonia) are presented.
Moreover, the relation between functional parameter calculated (for example, global incorporation rate constant, relative concentration coefficient, etc) in thyroid function studies and thyroid Tc99m-earlier uptake ratio (%) has been discussed by carrying out regression analysis.
