Abstract
In order to clarify the induction mechanism of the late cutaneous allergic respose (LCAR), the following were studied : 1) intracutaneous test with various kinds of allergens, 2) reversed type allergic resposes using anti-human IgE rabbit serum (aIgE), 3) P-K tests with several antigen-anti-body systems. Histopathological study of skin sites showing positive LCAR was performed. The following results were obtained :
1) The frequency of LCAR varied with the kind of allergen used. The type of LCAR (isolated or dual type ; immediate and late) depended on the kind of allergen.
2) Intracutaneous injection of aIgE also induced LCAR. There was no significant difference in the frequency of the response asthmatic patients and healthy volunteers.
3) LCAR was often detected 4-8hours after the immediate reaction in P-K tests. However, in some cases LCAR was observed in negative P-K tests.
4) Histological findings of LCAR showed edema in dermis, swollen collagen fibers and invasion of lymphcytes and polymorphnuclear leucocytes around blood vessels.
5) No correlation between the frequency of LCAR and IgE levels in the blood of the asthmatic patients was observed.
