Abstract
1) Maternal sera which had antibody titers more than 256 folds against husband's papain treated red cells after absorption of anti-A and anti-B natural antibodies with blood group substances, were selected as immune antibodies of ABO incompatibility between mother and fetus. Sixty two out of 632 mother's serum samples which reacted with husband's papain treated red cells after absorption of natural antibodies were attributed to ABO incompatibility cases. The distribution of the blood groups of the mothers with the immune antibody was higher in group O than in group A and B. The cases of anti-B antibody production in the group O mothers were higher than that of anti-A antibody production.
2) It was confirmed that natural and immune IgG anti-P was thought to be a cause of abortion early in pregnancy of group Ph mother.
3) Anti-M immune antibody reacted by the indirect antiglobulin method did not absorb on DEAE-cellulose and was found to be IgG class. Anti-Rho of incomplete type worked with the enzyme treated red cells and by the antiglobulin test belonged to IgG class, while the complete type antiserum which reacted with Rh positive saline red cells contained IgM and IgG antibodies. Subclasses of the immune IgG antibodies produced in the maternal sera were mainly IgG1 and IgG3 which pass from mother to fetus through placenta.
4) The immunoglobulin class of anti-H (E) antibody found in the serum of fibrosarcoma patient was IgM and IgA, and anti-e (hr″) from the patient of preleukemic stage belonged to IgM class.
