1991 Volume 41 Issue 1 Pages 153-157
Radioallergosorbent test (RAST) was performed for the measurement of anti-Mycoplasma pneumoniae (Mp) IgG, IgD, IgE and complement fixing (CF) antibodies and cold agglutinin (CA) in the sera of 25 patients with primary atypical pneumonia (PAP) and controls. Of infants three years old or younger, 11% were positive for CF antibody, whereas positive rates for IgD, IgG and IgE antibody to Mp were 100%, 44% and 12.5%, respectively. The positive rates for IgD and IgG antibody to Mp were higher than that of CF antibody. Levels of IgE antibody in patients with high CA titers were significantly higher than those in patients with low CA titers.
In conclusion, measurement of IgD and IgG antibody to Mp was useful in the serological diagnosis of infant Mp pneumonias. IgE antibody to Mp with cold agglutinin test would also support diagnosis in the cases with low CF titers.
