1992 Volume 42 Issue 6 Pages 661-666
A 54-year-old woman with ulcerative colitis coexisting with pyoderma gangrenosum and arthritis is presented. Colonoscopy showed severe inflammation on the left side of the colon and the findings of a biopsy specimen were compatible with active ulcerative colitis. Pyoderma gangrenosum was diagnosed on the basis of clinically and bacteriobogically negative findings. Colotic arthritis was rheumatoid factor negative and there were no radiographic findings. She was diagnosed as having an initial attack of the severe type of ulcerative colitis, and treated with enema adminstration of prednisolone and oral administration of salazosulfapyridine. Remission of colonic manifestations and the arthritis were obtained in accordance with normaligation of C reactive protein.
Extra-intestinal manifestations of ulcerative colitis are skin lesions, uveitis, arthralgis and arthritis, liver impairment, cholangitis and so on. Coexistence of pyoderma gangrenosum and arthritis with ulcerative colitis was rare in Japan according toour review of the Japanese literature.
