Abstract
A 31-year-old woman was admitted to hospital because of hyperglycemia in June 1997.
She had simple diabetic retinopathy. Conventional insulin therapy started since urinary C-peptide secretion was remarkably decreased (19μg/day). Intermediate type inslin dose was gradually increased from 8U (once a day) to 44U (twice a day) for 2 months. Fasting plasma glucose decreased from 403 mg/dl to 156 mg/dl. During this period, there were no hypoglycemia symptoms and no hypoglycemia was detected in the laboratory findings. In the middle of August, she experienced disturbance in her consciousness which worsened daily. Magnetic Resonance Imaging (MRI), revealed higt density areas along the gyrus in bilateral temporal, parietal and occipital lobes of the brain. This MRI finding is quite similar to that observed in patients with hypoglycemic coma. Her consciousness level further deteriorated, she fell into a coma, and finally died from septic shock.
