Abstract
Backgrounds and Aims : Hepatocellular carcinoma (HCC) is recently increasing in number and the gender differences have been epidemiologically demonstrated.
Patients and Methods : Patients with HCC treated in National Sanatorium Nishigunma Hospital in recent 10 years were clinicopathologically analyzed for their gender difference.
Results : Male patients with HCC were approximately 2.5 times more than female (189 : 74), namely 18. 9 male and 7.4 female patients with HCC were diagnosed in a year (P <0.01). The age at the diagnosis of male HCC was 62.89 and that of female was 66.91 This difference was significant in HCV positive patients (63.1 : 66.5, P < 0.01). The rate of habitual alcohol drinking, HBsAg positivity and progression of HCC itself was significantly more in male than female. The number of tumors and portal invasion were more in male than female. The functional reserve of the liver is not different between male and female in HCC patients. The male patients tended to survive shorter than female but in cases with hepatic tumor resection at the early stage, no differences of survival between them were demonstrated.
Conclusion : Distinct gender differences were demonstrated from the development to the progression of HCC. Gender differences should be taken into account for the clinical approach in patients with HCC.
