Influence of the Anti-agents Considered to Exist in the Infected Root Canals upon Germicidal of Homosulfamine

Abstract

When homosulf amine was used through root canal therapy, it has been known that the germicidal effect was reduced by anti-agents produced in the root canals. Among these anti-agents were necrotic tissues, pus, secretion and blood etc. In this experiment, therefore, it was tested how these unfavorable agents worked in vitro upon the germicidall effect of this medicine.
The chief results of this research are as follows:
1) Without anti-agents, the local use of 5% homosulfamine solution would be considered most effective in vitro.
2) By consideration of the time of 50% LD. of all amount of bacteria, the effect of 20% homosulfamine solution was remarkably reduced by pus only to show that of 5% solution.
3) 5% Homosulfamine solution was reduced by secretion or gelatine to 1.25% solution in the effect.
4) No change caused by serum was observed.
5) By using urea with homosulfamine, the reduction of the effect by pus could be abated.