Abstract
A 48×10^4IU/day urokinase (UK), which had been estimated by the appearance of fibrinolysis in the preceeding studies, was infused at the velocity of 12×10^4IU/h in 20 patients with various types of thrombosis. Infusion of UK resulted in a marked fibrinolysis characterized by a decrease of α_2-plasmin inhibitor to about 50% of the preinfusion value. Fibrinogen and α_2-macroglobulin also decreased to about 50% of the preinfusion value. PT, APTT and platelet aggregation were hardly changed during UK infusion. This UK therapy resulted in marked systemic fibrinolysis without inducing hypercoagulation.
