Abstract
A rare case of Stevens-Johnson syndrome associated with acute hepatitis was described. A 47-year-old man was admitted to the hospital because of generalized eruption. He had suffered with shoulder pain. Chlormezanone 600 mg a day was given for 9 days. Five days after cessation of this drug, he had fever with chill, and consulted us. The patient was diagnosed pharingitis, and prescribed talampicillin hydrochloride and diclofenac sodium. About two hours after taking talampicillin 500 mg and diclofenac 25 mg, generalized skin eruptions developed. Blood chemistry revealed GOT 1884 mIU, GPT 1434 mIU, T-Bil 2.6 mg/dl. Bullous and erythematous eruptions on general skin and erosive lesions on mucosa were seen. He was diagnosed Stevens-Johnson syndrome associated with acute hepatitis. Predonisolone (40mg a day) therapy was started, and the symptoms were improved rapidly. Both Stevens-Johnson syndrome and hepatitis are presumed to be induced by some of these drugs, although Lympheocyte Transformation Tests and patch tests were all negative.
