1987 Volume 18 Issue 2 Pages 175-178
The incidence of spontaneous abortion in our country is said to be about 10%. It is also reported that about 50% of the abortuses have chromosome abnormalities and there are some balanced translocation carriers among the aborting parents. Taking these data into consideration, chromosomal analyses were made on 74 couples who had experienced spontaneous abortion more than twice. As a result, three couples of them were found to be balanced translocation carriers(wives only in either case); respective chromosome karyotypes were 46, X X, t (2 ; 18) (q 32; q 23), 46, XX, t (2 ; 12) (p 15 ; P 13), 46, XX, t (9 ; 21) (q 32 ; q 22). Case 2 and 3 having children, further analyses were made on them. The studies revealed that one of the children had a normal karyotype and another was a balanced translocation carrier who had the same karyotype as its mother. In the event that balanced translocation carriers are found in couples with histories of miscarriage, genetic counselling is necessary for them thereafter, because of high recurrence risk of chromosomal abnormalities.
