Abstract
Eleven patients who had laryngeal squamous cell carcinoma were treated with intra-arterial chemoradiotherapy between 2004 and 2008 at the Kurume University Hospital. Five of the 11 patients had supraglottic cancer, others had glottic cancer, and 1 had subglottic cancer. Two patients were at Stage II, 7 patients were at Stage III, and 2 patients were at Stage IV A.
The treatment was intra-arterial CDDP (75-100mg⁄body) infusion using the Seldinger method together with irradiation (60-71Gy). All of the patients could be treated with intra-arterial chemoradiotherapy without having to stop the treatment. Complete remission was achieved in all patients, and we have not discovered the recurrence of any tumors yet. The laryngeal preservation rate was 100％. Observed side effects were as follows: 4 patients had Grade I pharyngitis, 2 patients had Grade I dermatitis from irradiation and 1 patient had Grade III pancytopenia. Intra-arterial chemoradiotherapy for laryngeal cancer may be the most effective treatment which allows for laryngeal preservation.
