Intralesional Cidofovir for Recurrent Laryngeal Papillomatosis

Abstract

The larynx is the most frequently affected organ by recurrent respiratory papillomatosis, caused by low-risk human papillomaviruses. Many treatment modalities including CO₂ laser surgery have been applied to control the disease. Cidofovir is an anti-viral agent and has been anticipated to eradicate human papillomavirus. Here, we summarize five cases of recurrent laryngeal papillomatosis, including two previously reported cases, treated with intralesional injection of the agent. The patients received local injections three times in four weeks. Post-treatment results were two disease free patients and minimal residual disease in two other patients; however, the disease worsened after a tentative mild regression in the remaining patient.