Evaluation of Superselective Intra-Arterial Chemotherapy for Laryngeal Cancer

Abstract

We performed clinical examination about the usefulness of the superselective intra-arterial chemotherapy for laryngeal cancer. The study group was composed 12 cases of glottic cancer and 9 with supraglottic cancer. Chemotherapy was performed through a catheter inserted into the superior thyroid artery via the forearm artery. The dose of cisplatin was 100mg/body per infusion session. A radiotherapy doses of 60Gy was performed in all cases.
All cases of glottic cancer exhibited a complete response (CR); however, there was local recurrence in two cases. While the survival rate was 100%, the laryngeal preservation rate was 83%.Eight cases of supraglottis cancer demonstrated CR, but one case had partial response (PR). Cervical lymph node recurrence was observed in two cases. The survival rate and the laryngeal preservation rate were 88%. Grade3 mucositis was observed in 12 cases. Superselective intra-arterial chemotherapy for laryngeal cancer was found to be one of the more effective treatments in larynx preservation.