Effect of Bevacizumab on Recurrent Laryngeal Papilloma

Abstract

Laryngeal papilloma is an intractable disease that can easily to recur. Therefore, it`s treatment is often difficult. We herein report a case of recurrent laryngeal papilloma successfully treated with bevacizumab. The patient was a woman in her 70 s. He was referred to our hospital with a chief complaint of hoarseness for the past six months. Laryngoscopy revealed a tumor behind the left vocal cord. A biopsy was performed under general anesthesia, and a diagnosis of laryngeal papilloma was made. Since the patient was undergoing systemic chemotherapy due to lung cancer, Yokuinin and Hochuekkito were administered, and the patient was followed up for laryngeal papilloma on an outpatient basis. After the laryngeal papilloma shrank, the respiratory physician administered bevacizumab. However, the laryngeal papilloma rapidly increased in size again after the administration of bevacizumab had been completed. Because of dyspnea, the tumor was debulked twice under general anesthesia. However, since recurrence of laryngeal papilloma was observed again, the administration of bevacizumab for lung cancer was started again. The laryngeal papilloma disappeared and her voice quality improved. He has been treated with bevacizumab once a month for more than two years without recurrence of laryngeal papilloma and maintains a good voice.