Leiomyosarcoma of the Larynx-A Case Report-

Abstract

Leiomyosarcoma of larynx is extremely rare. It accounts for approximately 5% of all soft-tissue sarcoma and occur the rate of 3% in the head and neck region. Leiomyosarcoma of larynx accounts for approximately 10% of all sarcoma in head and neck region.
A 56-year-old man was admitted to our hospital for a 2-month history of hoarseness. An excisional biopsy was performed using microlaryngoscopy. Histological examination revealed highgrade dysplasia. Subsequent clinical symptoms, however, indicated extreme deterioration. It was judged that the lesion had transformed into cancer. We used radiation and chemotherapy to treat the tumor. One year later, a recurrence in the subglottic area was found. This lesion was identified as leiomyosarcoma using pathological examination. We treated the tumor by total laryngectomy.
Immunohistochemical studies are helpful in making an unambiguous diagnosis. In this case, smooth muscle specific antigen and desmin was stained positively. The clinical course of this case suggested a pathogenesis of multiple primary malignancies rather one than radiation induced.