A Case Report of Lymphoproliferative Disease in Larynx with Chronic Active Epstein-Barr Virus Infection

Abstract

We initially report a 14-years old female case with chronic activity EB virus infection (CAEBV), suffered from dyspnea caused by proliferative granulation of bilateral vocal cords and supra glottic region.
CAEBV is in the condition which the activity of EB virus infection maintains over several months or more, and the number of EB virus infected cell or the amount of EB virus genemes is increasing. In this case, EBERI positive and granzyme B positive cells were varified by in situ hybridization, and diagnosed as NK cell dominant CAEBV.
CAEBV is the latest recognized EB virus related disease and doesn't established diagnostic standard. In cases of recurrent infectious mononucleosis and/or mosquito allergy, we need to consider to this disease.