Abstract
Recently, demand for ECMO (Extra-corporeal Membrane Oxygenation)，ECLS (Extra-corporeal Life Support)，PCPS (Percutaneous Cardiopulmonary Support) and long-term cardiopulmonary supports is expanding exponentially, however, membrane oxygenator still remain problem of long-term use. In this study, PFC (Perfluorocarbon)-Blood contact type oxygenator (PBC-OX) without hollow fiber was developed. PFC is harmless to the body, and has high gas solubility and insolubility in blood. When oxygenated PFC comes in contact with blood, blood gas exchange transpires and the PFC spontaneously separates from the blood because of its insolubility and higher specific gravity. In vitro experiments using bovine blood were carried out to evaluate the performance of PBC-OX. As the result, PaO2 and PaCO2 were kept in the normal value (PaO2 >80 mmHg, PaCO2<40 mmHg). The free hemoglobin concentration was less than 60 g/dl. These results show that the performance of PBC-OX is comparable to that of membrane oxygenators.
