Abstract
We examined the history of food allergy （FA） in patients at the University of Yamanashi Hospital who were hospitalized from 2019 to 2021 and developed allergic transfusion reactions （ATRs）. One hundred fifty-seven patients developed mild ATRs, among which 22 patients had a history of FA. Out of the 157 patients, 30 patients received red blood cell （RBC） transfusion, among which 20.0% （6/30） had FA. Thirty patients received fresh frozen plasma （FFP） transfusion, and 23.3% （7/30） of them had FA. Ninety-seven patients received platelet concentrate （PC） transfusion, and 9.3% （9/97） of them had FA. The FA history-positive rate was 21.7% （13/60） in patients who developed mild ATRs after RBC or FFP transfusion, which was significantly higher than that （11.1%, 4,380/39,473） in all patients hospitalized and that in patients without any adverse transfusion reactions （3.1%） during the same periods. We suggest the possibility that allergic food antigens included in blood products might partly （maximally 10%） be involved in the occurrence of mild ATRs after RBC or FFP transfusion. Despite the higher incidence of ATRs after PC transfusion, the involvement of FA was not demonstrated probably because more multimodal factors are implicated in ATRs after PC transfusion.
