Abstract
Basic methodology and recent technology of real-time imaging systems to observe brain activities by using voltage sensitive dyes (VSD) were described. By the pioneer studies that were done in 1970-80, it was shown that some dyes change their optical properties, like fluorescence, by neural activity. This finding enables us to obtain a multi site recording without any electrode. Recent image sensor technologies can provide high spatiotemporal resolution for brain activity recordings. We developed a CMOS imaging system which has 100x100 resolution and 0.1 msec scanning time for this purpose.
