Abstract
Photodynamic therapy (PDT) using 664-nm laser diode and talaporfi n sodium has been developed in
Japan as promising therapeutic technology. It has deeper light penetration and lower photosensitivity risk
than conventional PDT. In this article, we reviewed the development history of PDT in clinical practice
and irradiation technology, and summarized the latest development of talaporfi n sodium mediated PDT
for malignant brain tumor and local failure esophageal cancer after chemoradiotherapy or radiotherapy.
