Abstract
The computational simulation of an action mechanism in photodynamic therapy (PDT) allows for the
quantitative understanding of treatment outcomes that depend on various variables related to clinical
treatment conditions. To simulate a PDT effect, a singlet oxygen dose, which is the main factor that
causes cytotoxicity for treatment, is used for an index that describes the effect of PDT treatment. Based
on the singlet oxygen dose, the PDT treatment effect can be simulated by calculating the distribution of
light irradiation, calculating the singlet oxygen dose, and determining the necrosis area based on the singlet
oxygen dose in biotissues. This paper introduces computational simulation methods to estimate
photodynamic therapy and describes an overview of the computational evaluation of interstitial photodynamic
therapy for malignant brain tumors.
