Blood Glucose Measurement Using a Discrete Wavelength Quantum Cascade Laser

Abstract

In recent years, noninvasive blood glucose measurement technologies have become more desirable. In this paper, we describe a method, which performs noninvasive blood glucose measurements, based on mid-infrared absorption spectroscopy, and uses only a few wavenumbers to unconditionally measure blood glucose levels in vivo. We identified the regression of blood glucose levels using only three wavenumbers, which were selected in a series cross validation technique. We demonstrated the performance of this model through correlations among different types of data and constructed an attenuated total reflection spectrometer with discrete fixed wavelengths using three distributed feedback quantum cascade lasers. To improve the accuracy of the glucose measurement, we examined the stabilization of the relative absorbance intensity between wavelengths by equalizing the illuminance distribution.