Abstract
Spectrum of Raman scatting light obtained from a cell contains comprehensive information about molecular
vibration modes in the cell. Cell is a complex system that is composed of various elements including
genes, proteins, metabolites, and so on. Expression profiles of these elements are patterned into a finite
number of clusters via complicated cross-interactions between them, called “decrease of degree of freedom”,
which is a fundamental mechanism in biological behaviors. The fact that Raman spectrum has
been used as a cellular fingerprinting to identify type/state of cells indicates that Raman spectra are also
patterned. Therefore, Raman spectrum can be paired with gene expression profiles though the “decrease
of degree of freedom”, providing a mutually-prediction between Raman spectra and gene expression profiles.
Here, we describe the detail logic of the above concept with our experiments.
