Abstract
The treatment for severely ill patient with COVID-19 is a burden to hospital management. When a centrifugal blood pump is replaced with a peristaltic pump in an extracorporeal membrane oxygenation (ECMO) used for respiration failure, the cost would be effectively decreased because the peristaltic pump can be used for long periods without the need to replace expensive parts. Blood in the peristaltic pump flows with moving the roller which compresses fluid within the tube. Under inappropriate occlusion, red blood cells undergo the morphological change and finally hemolysis. To avoid such unfavorable processes, the appropriate occlusion must be kept during the treatment. In this review, we examined the literatures on mechanisms of the changes in morphology dependent on the occlusion and pursued the clue of early change of the morphology.
