INHIBITORY EFFECT OF SODIUM NITROPRUSSIDE ON THE DEVELOPMENT OF RESISTANCE OF ESCHERICHIA COLI TO STREPTOMYCIN

Abstract

Sodium nitroprusside was demonstrated to inhibit specifically the development of resistance of E. coli to streptomycin by a mechanism other than the suppressive effect on the growth of resistant mutants. The results obtained ledthe authors to assume that sodium nitroprusside interfers with some metabolic functions of the cells. This interference, thereby, inhibits the conversion from sensitive to resistant cells in the presence of streptomycin.