Abstract
Induction of chloramphenicol (CM) resistance in Staphylococcus aureus was investi-gated by using several CM derivatives. It was found that dl-threo-1-p-nitrophenyl-2-dichloroacetamino-1, 3-dichloropropane has high antibacterial activity but low activity of induction for CM resistance. In spite of low antibacterial activity, induction of CM resistance occurred after prior treatment with dl-threo-1-p-nitrophenyl-2-dichloro-acetamino-3-chloropropane-1-ol. It was found that dl-chloramphenicol di-acetate, dl-threo-1-p-nitrophenyl-2-dichloroacetamino-3-bromopropane-1-ol and dl-threo-1-phenyl-2-dichloroacetamino-1, 3-propanediol have induction ability in spite of the absence of antibacterial activity. Other derivatives were classified into two groups; (1) low anti-bacterial activity and induction of CM resistance and (2) loss of both activities.
