Drug Resistance of Staphylococci

Ability of Chloramphenicol Related Compounds to Induce Chloramphenicol Resistance in Staphylococcus aureus

Abstract

Induction of chloramphenicol (CM) resistance in Staphylococcus aureus was investi-gated using 166CM derivatives and analogues. It was found that 18 compounds of the samples used were able to induce resistance to CM in Staphylococcus aureus S1477 harboring an inducible CM-resistance determinant. Most of the samples which had a nitrophenyl moiety and a D-or DL-threo isomer in its steric configuration were found to have inducer activity for CM resistance. Competent inducers are D-isomer CM derivatives which have another substituent in place of the hydroxyl group at carbon atom 3 in the propanediol of the drug.