Inhibition of Host Deoxyribonucleic Acid Synthesis after Infection of Ultraviolet-Irradiated Measles Virus

Abstract

Measles virus suppressed cellular DNA synthesis two hours after infection but did not inhibit RNA or protein syntheses. The suppression of DNA synthesis was not dependent on the cellular growth phase but was dependent on the multiplicity of infection. This activity of measles virus was inactivated neither by ultraviolet-irradiation nor by heating at 56C for two hours, but was lost after treatment with a convalescent antiserum of a measles patient or with proteolytic enzymes (pronase and trypsin).