Replication of Adenovirus 12 Deoxyribonucleic Acid in Association with the Nuclear Membrane

Tadashi YAMASHITA; Hiroto SHIMOJO

doi:10.1111/j.1348-0421.1973.tb00793.x

Tadashi YAMASHITA, Hiroto SHIMOJO

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JOURNAL FREE ACCESS

1973 Volume 17 Issue 5 Pages 419-423

DOI https://doi.org/10.1111/j.1348-0421.1973.tb00793.x

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Abstract

Analysis of nuclei of adenovirus 12-infected cells revealed that viral DNA replicated in association with the nuclear membrane and that complete viral DNA was liberated from the nuclear membrane. Analysis of isolated nuclei in vitro showed that DNA polymerase activity increased in the nuclear membrane of adenovirus 12-infected cells without addition of primer DNA.

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