Antiinfluenzal Effect of Rugulosin

Abstract

(-)Rugulosin showed an antiinfluenzal effect in the allantoic cavity of chicken eggs as well as in cultured chorioallantois, proving itself to be more potent than 1-adamantanamine. Also, (-)rugulo-sin, when administered by inhalation, was as effective for protection of mice against aerosol influenzal infection as orally administered 1-adamantanamine. The effect of (-)rugulosin seemed to be mainly due to direct inactivation of influenza virus.