Experimental Salmonellosis

XV. The Role of Cellular Antibody in the Development of Cellular Immunity

Abstract

An immune ribonucleic acid (RNA) preparation was obtained from the spleens of mice immunized with a live vaccine of Salmonella enteritidis. When peritoneal macrophages were infected with S. enteritidis 116-54 which had been treated by mixed cultivation with the peritoneal exudate cells of mice previously treated with an immune RNA preparation, they showed cellular resistance against the infecting bacteria, According to the results described previously and those described in this article, it can be concluded that the cellular resistance against an infection with S. enteritidis is traceable to a cellular antibody (or antibodies) detected in macrophages of mice immunized with a live vaccine of the same organism or of mice treated in viva (or in vitro) with an immune RNA preparation.