MICROBIOLOGY and IMMUNOLOGY
Online ISSN : 1348-0421
Print ISSN : 0385-5600
ISSN-L : 0385-5600
Modulation by Polymyxin B of the Effects of Interferon on Human Myelogenous Leukemia Cells
Minori TamuraYasuiti Nagano
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1994 Volume 38 Issue 5 Pages 407-411

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Abstract

Natural and recombinant human interferon-α (IFN-α) and-γ (IFN-γ) exert differentiation-inducing and cytocidal effects in vitro on cells of the human myeloblastic leukemia cell line ML-2. These activities of IFNs are modulated by polymyxin B (PMB), a cyclic polycationic peptide antibiotic effective on Gram-negative bacilli. The modulating effect of PMB varies according to the species of IFN, namely, PMB enhances the activities of either natural IFN-γ or recombinant IFN-γ, while it inhibits the effects of either natural IFN-α or recombinant IFN-α. The cause of this variety in PMB effect on IFNs remains to be clarified.

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