Emergence of New Influenza A Viruses Which Carry an Escape Mutation of the HLA-B27-Restricted CTL Epitope of NP in Japan

Takahito Kashiwagi; Nobuyuki Hamada; Jun Iwahashi; Koyu Hara; Tatsuo Ueda; Hidetaro Noguchi; Tetsuya Toyoda

Takahito Kashiwagi, Nobuyuki Hamada, Jun Iwahashi, Koyu Hara, Tatsuo Ueda, Hidetaro Noguchi, Tetsuya Toyoda

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Keywords: Influenza virus, NP, CTL epitope, HLA-B27

JOURNAL FREE ACCESS

2000 Volume 44 Issue 10 Pages 867-870

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Abstract

Influenza A viruses (H3N2) isolated in 1998 in Nagasaki, Japan, carried a mutation (384R→G) in one of the anchor amino acids of the HLA-B27-restricted cytotoxic T lymphocyte (CTL) epitope of NP (383-391). Phylogenetic analysis revealed that these viruses have been isolated only in Japan to date and belong to the unique lineages.

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