Decline in the HIV-1 Isolation Rate in Japan A 12-Year Observation

Tadashi Nakasone; Junki Takamatsu; Kuhomi Watanabe; Satoshi Naganawa; Kenji Someya; Naoto Yoshino; Masahiko Kaizu; Takeaki Ohsu; Mari Takizawa; Yasuyuki Izumi; Mamoru Kawahara; Takashi Hara; Yoshihiro Fujimura; Kaneo Yamada; Yoshiyuki Nagai; Shudo Yamazaki; Mitsuo Honda

Decline in the HIV-1 Isolation Rate in Japan

A 12-Year Observation

Tadashi Nakasone, Junki Takamatsu, Kuhomi Watanabe, Satoshi Naganawa, Kenji Someya, Naoto Yoshino, Masahiko Kaizu, Takeaki Ohsu, Mari Takizawa, Yasuyuki Izumi, Mamoru Kawahara, Takashi Hara, Yoshihiro Fujimura, Kaneo Yamada, Yoshiyuki Nagai, Shudo Yamazaki, Mitsuo Honda

Author information

Tadashi Nakasone
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Japan Science and Technology Corporation
Junki Takamatsu
Department of Blood Transfusion, Nagoya University Hospital
Kuhomi Watanabe
Department of Microbiology and Immunology, Nippon Medical School
Satoshi Naganawa
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Kenji Someya
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Japan Science and Technology Corporation
Naoto Yoshino
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Masahiko Kaizu
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Japan Science and Technology Corporation
Takeaki Ohsu
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Japan Science and Technology Corporation
Mari Takizawa
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Japan Science and Technology Corporation
Yasuyuki Izumi
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Japan Science and Technology Corporation
Mamoru Kawahara
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Takashi Hara
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Yoshihiro Fujimura
Department of Blood Transfusion Service and Second Department of Internal Medicine, Nara Medical University
Kaneo Yamada
Institute of Medical Sciences, St. Marianna University of Medicine
Yoshiyuki Nagai
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Shudo Yamazaki
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Japan Science and Technology Corporation
Mitsuo Honda
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
Japan Science and Technology Corporation

Keywords: HIV-1, Virus isolation, Japan

JOURNAL FREE ACCESS

2000 Volume 44 Issue 11 Pages 949-952

Details

Abstract

Since 1988, we have isolated HIV-1 from 614 HIV-1-infected persons (total sample=2, 785) in Japan. During the past 12 years, we have found a decline in the HIY-1 isolation rate in Japan, with two identifiable turning points, 1991-1992 and 1996-1997. The two turning points correspond to shifts in anti-HIV-1 therapy. These findings suggest that HIV-1 in Japan is currently biologically well controlled, probably due to anti-HIV-1 therapy. On the other hand, this decline is inconsistent with the recent increase of genetic drug-resistant HIV-1 in Japan. Further studies are needed to clarify mechanisms that might explain the discrepancy.

Corresponding author

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