Nihon Ika Daigaku Igakkai Zasshi
Online ISSN : 1880-2877
Print ISSN : 1349-8975
ISSN-L : 1349-8975
Hyperglycemia and Atherosclerosis: Experimental Results in Mice
Akira Asai
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2017 Volume 13 Issue 4 Pages 194-198

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Abstract

Epidemiological evidence indicates that patients with diabetes mellitus are at increased risk for atherosclerotic cardiovascular and cerebrovascular diseases. Furthermore, recent reports have demonstrated that the risk for atherosclerotic events is increased even in individuals in a pre-diabetic state, for example in those with impaired glucose tolerance. Although a number of studies have investigated the molecular mechanisms underlying the causal role of hyperglycemia (both chronic and transient) in the pathogenesis of atherosclerosis, little compelling evidence has been found in vivo. This article summarizes the potentials and pitfalls of using mouse models to study hyperglycemia-induced atherosclerosis in the hope of elucidating its complicated molecular mechanisms.

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© 2017 by the Medical Association of Nippon Medical School
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