3. Gene Delivery and Expression Series Viral Vector Mediated Gene Delivery and Expression (5)

Abstract

Most of the candidate tissues for in vivo gene transfer are made of quiescent cells, such as from the brain, liver, and muscle. Thus, the optimal vector should infect non-dividing cells. Recently, many type of adeno-associated virus (AAV) vectors have been developed and used in vivo gene transfer. This technical note focuses on the in vivo gene transfer using AAV vectors. We discuss about how to choose the appropriate viral vector to transduce target organs in vivo.