An Interface for Liquid Chromatograph/Mass Spectrometer Using Atmospheric Pressure Ionization Coupled with a Nebulizing Sample Introduction System

Abstract

An interface for liquid chromatograph/mass spectrometer (LC/MS) using atmospheric pressure ionization (API) coupled with a nebulizing sample introduction system is mounted on a single focusing mass spectrometer. Many kinds of nonvolatile compounds are investigated. Comparison between API and chemical ionization (CI) and/or molecular secondary ion mass spectra are carried out. It is demonstrated that a few ng sample can be detected in this LC/APIMS system.