Stereochemical Effects in Chemical Ionization Mass Spectrometry Using Chiral Reagent Gases

Abstract

The gas chromatographic resolution of isoborneol and borneol enantiomers were achieved by capillary column coated with chiral stationary phase. The gas chromatography/chemical ionization mass spectrometry (GC/CIMS) were performed using (S)-(+)-1-amino-2-propanol, (R)-(−)-1-amino-2-propanol, (S)-(+)-2-amino-1-propanol, and (R)-(−)-2-amino-1-propanol as chiral reagent gases. The CI mass spectra could be obtained with good reproducibilities. It was found that the CI mass spectra of the enantiomers could be distinguished when a chiral reactant ion attached to a chiral functional group of the sample molecule.