Abstract
Assessment of human drug metabolism is necessary for the evaluation of drug efficacy and safety. Studies on molecular cloning of drug metabolizing enzymes indicate the limited values of experimental animal data for the extrapolation to humans. Recent progress on the secondary structures of cytochrome P450 forms, however, provide an alternate predicting way through modeling of substrate contact environments of P450 forms. Usefulness of this approach is discussed with CYP2C P450 data.
