Abstract
As the development of X-ray crystallography and NMR, tertiary structure of proteins has come to be investigated more precisely than before. Mass spectrometry is also an effective tool to analyze the structure of large biomolecules. In addition, computational chemistry enables to study the protein-ligand interaction. This commentary explains how effective mass spectrometry and computational chemistry are in the analysis of structure-function relationships of biomolecule networks, indicating the results of mass spectrometric characterization of immunoglobulin G2b and analysis of computational chemistry of the binding of immunoglobulin G2b and its receptor.
