Abstract
Since advent of atmospheric pressure ionization technique, LC/MS had been used very often for bioanalysis at early to late drug development stage. Then, LC/MS have been principal equipment for bioanalysis especially for high sensitivity and high throughput purposes, at present. Lately, the automatic sample pretreatment using robotics accelerates the improvement of throughput and releases a researcher from pretreatment work. On the other side, high speed analysis methods carried some problems for misunderstanding of analytical data. Still, those problems could be manageable with appropriate expertise and experience.
