The Role of Mass Spectrometry for Safety Evaluation in the Drug Discovery Stage

Abstract

Recent advances in drug discovery technologies require a paradigm shift in safety evaluation of drug candidates, especially with respect to their toxicological contribution at the early stage of drug discovery. In this context, new sciences and technologies should be implemented in the field of safety evaluation, and the numerous applications of mass spectrometry (MS) are thought to be one of the key approaches. In the present review, we have summarized the usability of MS and its practical applications in early safety evaluation.