Lipidomic Variations by the Oxidative Stress in the Space Flight

Abstract

Space travel induces stresses that provoke health problems, and concomitantly induces the expression of Nrf2 (NF-E2-related factor-2) target genes that mediate adaptive responses to oxidative and other stresses. While the variation of lipid species in white adipocytes (eWAT) have been identified, detailed changes of lipid profiles, such as the level of fatty acid, remain unknown. Therefore, we have analyzed eWAT and liver tissues of flight mice and ground control including wild type and Nrf2 knockout mice by means of the lipidomic profiling using a UHPLC-FTMS. The level of eicosapentaenoic acid (EPA) type of phospholipids were significantly increased after space flight, suggesting that EPA may be the key factor for the novel function involved in antioxidant effects of Nrf2 in the space flight.