Study on Drug Metabolites by Mass Spectrometry(VI)

Metabolites of Glifanan in Rats

Abstract

In a previous paper, we reported the availability of mass spectrometry as a useful technique for the identification of drug metabolites. In this paper, the metabolites excreted in urine and bile following oral administration of 4-[2'-(2″, 3″-Dihydroxy propoxy carbonyl)phenylamino]7-chloroquinoline (I) in rats were investigated by a mass spectrometric technique as shown in Fig. 2. Of the six metabolites suspected to be present in urine and eight metabolites in bile, the structures of three metabolites were elucidated to be 4-[2'-(2″, 3″-Dihydroxy propoxy carbonyl) phenylamino]7-chloroquirioline (I), 4-[2'-(Carboxyl)phenylamino]7-chloroquinoline (II) and 4-[2'-(Carboxymethyl)phenylamino]7-chloroquinoline (IV) .