Peptide Synthesis

Abstract

Unlike reagent controlled reactions (mechanism controlled reactions) which played significant role in organic synthesis in the past, substrate controlled reactions are relatively newer approach. Nevertheless, since its discovery the latter has become an indispensible tool in modern synthesis. In these reactions, an electron donor polar substituent in the substrate, namely a “directing group”, actively facilitates the transient interplay between the substrate and the reagent via nonbonding interaction, in such a fashion that the incoming group attacks stereoselectively. Thus the stereochemical outcome of a reaction is largely dependent on the nature of the substrate. I will describe our approach for the substrate controlled chemical reaction and its applications for peptide synthesis. Peptide synthesis is the most important research in this century for drug design and synthesis. The detailed background for this chemistry is described.