Abstract
A number of S-alkyl O-alkyl O-aryl phosphorothiolothionates and thiolates were examined for their toxicities to mice, and organophosphorus insecticide resistant and susceptible strains of house flies. These new asymmetrical phosphorothiolothionates and thiolates having S-n-propyl showed exceptionally higher activity against both susceptible and resistant house flies than the corresponding analogues having other alkyl moieties. Usually low mammalian toxicity was demonstrated by the O-ethyl S-n-propyl O-substituted phenyl phosphoro-thiolothionates. Considering mammalian toxicity and insecticidal activity, prothiophos and its oxygen analogue are the preferred compounds as novel hygienic insecticides in the series.
